1orl

From Proteopedia

(Difference between revisions)

Current revision

1H NMR structure determination of Viscotoxin C1

Structural highlights

1orl is a 1 chain structure with sequence from Viscum album. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 10 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THNC_VISAL

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The high resolution three-dimensional structure of the newly discovered plant viscotoxin C1, from the Asiatic Viscum album ssp. Coloratum ohwi, has been determined in solution by (1)H NMR spectroscopy at pH 3.6 and 285 K. The viscotoxin C1-fold, consisting of a helix-turn-helix motif and a short stretch of an antiparralel beta-sheet is very similar to that found for the highly similar viscotoxins A2 and A3 and for other related thionins. Different functional properties of members of the thionin family are discussed here in light of the structural and electrostatic properties. Among the very homologous family of alpha- and beta-thionins, known for their antimicrobial activity, the viscotoxin subfamily differs from the other members because of its high toxicity against tumoral cells. Key residues for the modulation of viscotoxin cytotoxicity have been identified on the basis of sequence and structural alignment.

NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins.,Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H Biochemistry. 2003 Nov 4;42(43):12503-10. PMID:14580196^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H. NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins. Biochemistry. 2003 Nov 4;42(43):12503-10. PMID:14580196 doi:10.1021/bi034762t

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1orl"

@@ Line 1: / Line 1: @@
 ==1H NMR structure determination of Viscotoxin C1==
-<StructureSection load='1orl' size='340' side='right' caption='[[1orl]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1orl' size='340' side='right'caption='[[1orl]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ed0|1ed0]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [http://pdbe.org/1orl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [http://www.ebi.ac.uk/pdbsum/1orl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [https://pdbe.org/1orl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [https://www.ebi.ac.uk/pdbsum/1orl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/THNB_VISAL THNB_VISAL]] Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.[REFERENCE:3]
+[https://www.uniprot.org/uniprot/THNC_VISAL THNC_VISAL]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1orl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1orl_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Viscum album]]
-[[Category: Catalano, M]]
+[[Category: Catalano M]]
-[[Category: Fogolari, F]]
+[[Category: Fogolari F]]
-[[Category: Giannattasio, M]]
+[[Category: Giannattasio M]]
-[[Category: Molinari, H]]
+[[Category: Molinari H]]
-[[Category: Ragona, L]]
+[[Category: Ragona L]]
-[[Category: Romagnoli, S]]
+[[Category: Romagnoli S]]
-[[Category: Urech, K]]
+[[Category: Urech K]]
-[[Category: Beta-sheet]]
-[[Category: Concentric motif of disulphide bridge]]
-[[Category: Helix-turn-helix]]
-[[Category: Toxin]]

1orl

From Proteopedia

Current revision

1H NMR structure determination of Viscotoxin C1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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