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5j3l

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==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution==
==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution==
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<StructureSection load='5j3l' size='340' side='right' caption='[[5j3l]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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<StructureSection load='5j3l' size='340' side='right'caption='[[5j3l]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j3l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J3L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J3L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6FR:1-[(2-CYCLOPENTYLETHYL)SULFONYL]PYRROLIDINE'>6FR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3l OCA], [http://pdbe.org/5j3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j3l RCSB], [http://www.ebi.ac.uk/pdbsum/5j3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3l ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FR:1-[(2-CYCLOPENTYLETHYL)SULFONYL]PYRROLIDINE'>6FR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3l OCA], [https://pdbe.org/5j3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j3l RCSB], [https://www.ebi.ac.uk/pdbsum/5j3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ETHR_MYCTO ETHR_MYCTO]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j3l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j3l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C]]
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[[Category: Large Structures]]
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[[Category: Blaszczyk, M]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blundell, T L]]
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[[Category: Abell C]]
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[[Category: Nikiforov, P O]]
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[[Category: Blaszczyk M]]
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[[Category: Surade, S]]
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[[Category: Blundell TL]]
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[[Category: Boosting effect]]
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[[Category: Nikiforov PO]]
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[[Category: Ethr]]
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[[Category: Surade S]]
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[[Category: Represor]]
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[[Category: Transcription]]
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Current revision

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution

PDB ID 5j3l

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