5mu8
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | ||
==HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525== | ==HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525== | ||
| - | <StructureSection load='5mu8' size='340' side='right' caption='[[5mu8]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='5mu8' size='340' side='right'caption='[[5mu8]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5mu8]] is a 48 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU8 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5mu8]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JNI:~{N}4-(PHENYLMETHYL)-~{N}4-[2-[3-(2-PIPERAZIN-1-YLPYRIMIDIN-5-YL)PHENYL]PHENYL]PYRIMIDINE-2,4-DIAMINE'>JNI</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JNI:~{N}4-(PHENYLMETHYL)-~{N}4-[2-[3-(2-PIPERAZIN-1-YLPYRIMIDIN-5-YL)PHENYL]PHENYL]PYRIMIDINE-2,4-DIAMINE'>JNI</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu8 OCA], [https://pdbe.org/5mu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu8 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[https://omim.org/entry/607507 607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 21: | ||
</div> | </div> | ||
<div class="pdbe-citations 5mu8" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5mu8" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Tumor necrosis factor|Tumor necrosis factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Blevitt | + | [[Category: Homo sapiens]] |
| - | [[Category: Hack | + | [[Category: Large Structures]] |
| - | [[Category: Herman | + | [[Category: Blevitt JM]] |
| - | [[Category: Jackson | + | [[Category: Hack MD]] |
| - | [[Category: Krawczuk | + | [[Category: Herman KL]] |
| - | [[Category: Lebsack | + | [[Category: Jackson PF]] |
| - | [[Category: Liu | + | [[Category: Krawczuk PJ]] |
| - | [[Category: Lumb | + | [[Category: Lebsack AD]] |
| - | [[Category: Milla | + | [[Category: Liu AX]] |
| - | [[Category: Mirzadegan | + | [[Category: Lumb KJ]] |
| - | [[Category: Nelen | + | [[Category: Milla ME]] |
| - | [[Category: Patrick | + | [[Category: Mirzadegan T]] |
| - | [[Category: Steinbacher | + | [[Category: Nelen MI]] |
| - | + | [[Category: Patrick AP]] | |
| - | + | [[Category: Steinbacher S]] | |
| - | + | ||
Current revision
HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525
| |||||||||||
Categories: Homo sapiens | Large Structures | Blevitt JM | Hack MD | Herman KL | Jackson PF | Krawczuk PJ | Lebsack AD | Liu AX | Lumb KJ | Milla ME | Mirzadegan T | Nelen MI | Patrick AP | Steinbacher S
