5u9s
From Proteopedia
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==Ocellatin-F1, solution structure in TFE by NMR spectroscopy== | ==Ocellatin-F1, solution structure in TFE by NMR spectroscopy== | ||
| - | <StructureSection load='5u9s' size='340' side='right' caption='[[5u9s | + | <StructureSection load='5u9s' size='340' side='right'caption='[[5u9s]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5u9s]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U9S OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5u9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptodactylus_labyrinthicus Leptodactylus labyrinthicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U9S FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u9s OCA], [https://pdbe.org/5u9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u9s RCSB], [https://www.ebi.ac.uk/pdbsum/5u9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u9s ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OCEF1_LEPLB OCEF1_LEPLB] Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) and Gram-positive bacteria (S.aureus) with relatively low potencies (MIC=25-400 uM) (By similarity) (PubMed:28115922). Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (PubMed:28115922). In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (PubMed:26635873). The peptide shows very low hemolytic activity against rabbit erythrocytes (By similarity) (PubMed:28115922). The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (By similarity).[UniProtKB:P0DQJ8]<ref>PMID:26635873</ref> <ref>PMID:28115922</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Leptodactylus labyrinthicus]] |
| - | [[Category: | + | [[Category: Gusmao KAG]] |
| - | [[Category: | + | [[Category: Pilo-Veloso D]] |
| - | [[Category: | + | [[Category: Resende JM]] |
| - | [[Category: Santos | + | [[Category: Santos VM]] |
| - | [[Category: | + | [[Category: De Lima ME]] |
| - | [[Category: | + | [[Category: Dos Santos DM]] |
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Current revision
Ocellatin-F1, solution structure in TFE by NMR spectroscopy
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