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| - | | + | #REDIRECT [[6alh]] This PDB entry is obsolete and replaced by 6alh |
| - | ==CryoEM structure of E.coli RNA polymerase elongation complex==
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| - | <StructureSection load='5upc' size='340' side='right' caption='[[5upc]], [[Resolution|resolution]] 4.38Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5upc]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPC FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5upa|5upa]]</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upc OCA], [http://pdbe.org/5upc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upc RCSB], [http://www.ebi.ac.uk/pdbsum/5upc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upc ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/RPOC_ECOLI RPOC_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322] [[http://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/RPOZ_ECOLI RPOZ_ECOLI]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.[HAMAP-Rule:MF_00366] [[http://www.uniprot.org/uniprot/RPOB_ECOLI RPOB_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321]
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: DNA-directed RNA polymerase]]
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| - | [[Category: Darst, S A]]
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| - | [[Category: Kang, J Y]]
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| - | [[Category: Bacterial transcription]]
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| - | [[Category: Dna-dependent rna polymerase]]
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| - | [[Category: Ternary elongation complex]]
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| - | [[Category: Transcription arrest]]
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| - | [[Category: Transcription-dna-rna complex]]
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