This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4omk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:16, 20 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of SPF bound to squalene==
==Crystal structure of SPF bound to squalene==
-
<StructureSection load='4omk' size='340' side='right' caption='[[4omk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+
<StructureSection load='4omk' size='340' side='right'caption='[[4omk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4omk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4omk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OMK FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SQL:(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE'>SQL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1olm|1olm]], [[1o6u|1o6u]], [[4omj|4omj]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SQL:(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE'>SQL</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omk OCA], [http://pdbe.org/4omk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4omk RCSB], [http://www.ebi.ac.uk/pdbsum/4omk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4omk ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4omk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omk OCA], [https://pdbe.org/4omk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4omk RCSB], [https://www.ebi.ac.uk/pdbsum/4omk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4omk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/S14L2_HUMAN S14L2_HUMAN]] Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
+
[https://www.uniprot.org/uniprot/S14L2_HUMAN S14L2_HUMAN] Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cascella, M]]
+
[[Category: Homo sapiens]]
-
[[Category: Christen, M]]
+
[[Category: Large Structures]]
-
[[Category: Lamprakis, C]]
+
[[Category: Cascella M]]
-
[[Category: Marcaida, M J]]
+
[[Category: Christen M]]
-
[[Category: Stocker, A]]
+
[[Category: Lamprakis C]]
-
[[Category: 3-oxidosqualene]]
+
[[Category: Marcaida MJ]]
-
[[Category: Cholesterol synthesis]]
+
[[Category: Stocker A]]
-
[[Category: Cral-trio domain]]
+
-
[[Category: Hydrophobic ligand transporter]]
+
-
[[Category: Sec14-like]]
+
-
[[Category: Squalene]]
+
-
[[Category: Transport protein]]
+

Current revision

Crystal structure of SPF bound to squalene

PDB ID 4omk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4omk"
Personal tools