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1i4g

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==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==
==Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity==
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<StructureSection load='1i4g' size='340' side='right' caption='[[1i4g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1i4g' size='340' side='right'caption='[[1i4g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1i4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I4G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sxt|1sxt]], [[1efs|1efs]], [[1i4h|1i4h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [http://pdbe.org/1i4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [http://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4g OCA], [https://pdbe.org/1i4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i4g RCSB], [https://www.ebi.ac.uk/pdbsum/1i4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
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[https://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4g_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4g_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Antonsson, P]]
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[[Category: Large Structures]]
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[[Category: Bjork, P]]
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[[Category: Staphylococcus aureus]]
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[[Category: Hakansson, M]]
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[[Category: Antonsson P]]
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[[Category: Svensson, L A]]
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[[Category: Bjork P]]
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[[Category: Beta-barrel]]
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[[Category: Hakansson M]]
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[[Category: Beta-grasp]]
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[[Category: Svensson LA]]
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[[Category: Toxin]]
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Current revision

Crystal structure of Staphylococcal enterotoxin A mutant H187A with reduced Zn2+ affinity

PDB ID 1i4g

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