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5naf

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==Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain==
==Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain==
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<StructureSection load='5naf' size='340' side='right' caption='[[5naf]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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<StructureSection load='5naf' size='340' side='right'caption='[[5naf]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5naf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NAF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5naf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NAF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.493&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5naf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5naf OCA], [http://pdbe.org/5naf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5naf RCSB], [http://www.ebi.ac.uk/pdbsum/5naf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5naf ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5naf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5naf OCA], [https://pdbe.org/5naf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5naf RCSB], [https://www.ebi.ac.uk/pdbsum/5naf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5naf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBL1R_MOUSE TBL1R_MOUSE]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). [[http://www.uniprot.org/uniprot/MECP2_MOUSE MECP2_MOUSE]] Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).<ref>PMID:23434322</ref>
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[https://www.uniprot.org/uniprot/TBL1R_MOUSE TBL1R_MOUSE] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cook, A G]]
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[[Category: Large Structures]]
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[[Category: Kruusvee, V]]
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[[Category: Mus musculus]]
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[[Category: Protein-peptide complex]]
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[[Category: Cook AG]]
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[[Category: Rett syndrome]]
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[[Category: Kruusvee V]]
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[[Category: Transcription]]
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[[Category: Transcriptional repressor]]
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[[Category: Wd40 domain]]
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Current revision

Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain

PDB ID 5naf

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