5m7t

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==Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor==
==Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor==
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<StructureSection load='5m7t' size='340' side='right' caption='[[5m7t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5m7t' size='340' side='right'caption='[[5m7t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m7t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M7T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M7T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDV:(5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE'>GDV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7t OCA], [http://pdbe.org/5m7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7t RCSB], [http://www.ebi.ac.uk/pdbsum/5m7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7t ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDV:(5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE'>GDV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7t OCA], [https://pdbe.org/5m7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m7t RCSB], [https://www.ebi.ac.uk/pdbsum/5m7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
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[https://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5m7t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5m7t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[O-GlcNAcase|O-GlcNAcase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Britton, R]]
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[[Category: Homo sapiens]]
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[[Category: Chan, S]]
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[[Category: Large Structures]]
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[[Category: Davies, G J]]
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[[Category: Britton R]]
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[[Category: Hemsworth, G R]]
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[[Category: Chan S]]
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[[Category: King, D]]
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[[Category: Davies GJ]]
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[[Category: Offen, W A]]
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[[Category: Hemsworth GR]]
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[[Category: Roth, C]]
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[[Category: King D]]
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[[Category: Varghese, V]]
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[[Category: Offen WA]]
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[[Category: Vocadlo, D J]]
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[[Category: Roth C]]
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[[Category: Willems, L I]]
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[[Category: Varghese V]]
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[[Category: Glcnac]]
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[[Category: Vocadlo DJ]]
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[[Category: Human glacoside hydrolase]]
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[[Category: Willems LI]]
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[[Category: Hydrolase]]
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Current revision

Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor

PDB ID 5m7t

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