5aoe

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==Crystal structure of pneumolysin D168A mutant.==
==Crystal structure of pneumolysin D168A mutant.==
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<StructureSection load='5aoe' size='340' side='right' caption='[[5aoe]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5aoe' size='340' side='right'caption='[[5aoe]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5aoe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5aoe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AOE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aod|5aod]], [[5aof|5aof]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoe OCA], [http://pdbe.org/5aoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aoe RCSB], [http://www.ebi.ac.uk/pdbsum/5aoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoe OCA], [https://pdbe.org/5aoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aoe RCSB], [https://www.ebi.ac.uk/pdbsum/5aoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
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[https://www.uniprot.org/uniprot/TACY_STRR6 TACY_STRR6] A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.[UniProtKB:P13128]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Cytolysin|Cytolysin]]
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pee, K van]]
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[[Category: Large Structures]]
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[[Category: Yildiz, O]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Cholesterol dependent cytolysin]]
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[[Category: Yildiz O]]
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[[Category: Pore forming toxin]]
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[[Category: Van Pee K]]
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[[Category: Toxin]]
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Current revision

Crystal structure of pneumolysin D168A mutant.

PDB ID 5aoe

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