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5lu9

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==Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11==
==Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11==
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<StructureSection load='5lu9' size='340' side='right' caption='[[5lu9]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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<StructureSection load='5lu9' size='340' side='right'caption='[[5lu9]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lu9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LU9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lu9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LU9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Y7:7-(MORPHOLIN-4-YL)-2,1,3-BENZOXADIAZOL-4-AMINE'>3Y7</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=3Y7:7-(MORPHOLIN-4-YL)-2,1,3-BENZOXADIAZOL-4-AMINE'>3Y7</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_002086:ACE-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE'>PRD_002086</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Legumain Legumain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.34 3.4.22.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu9 OCA], [https://pdbe.org/5lu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lu9 RCSB], [https://www.ebi.ac.uk/pdbsum/5lu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu9 OCA], [http://pdbe.org/5lu9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lu9 RCSB], [http://www.ebi.ac.uk/pdbsum/5lu9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
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[https://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Legumain]]
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[[Category: Homo sapiens]]
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[[Category: Brandstetter, H]]
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[[Category: Large Structures]]
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[[Category: Dall, E]]
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[[Category: Synthetic construct]]
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[[Category: Ye, K]]
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[[Category: Brandstetter H]]
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[[Category: Allosteric inhibitor]]
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[[Category: Dall E]]
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[[Category: Alzheimer's disease]]
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[[Category: Ye K]]
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[[Category: Asparaginyl endopeptidase]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11

PDB ID 5lu9

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