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5lub

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==Crystal structure of human legumain (AEP) in complex with compound 11==
==Crystal structure of human legumain (AEP) in complex with compound 11==
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<StructureSection load='5lub' size='340' side='right' caption='[[5lub]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5lub' size='340' side='right'caption='[[5lub]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lub]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LUB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LUB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Y7:7-(MORPHOLIN-4-YL)-2,1,3-BENZOXADIAZOL-4-AMINE'>3Y7</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Y7:7-(MORPHOLIN-4-YL)-2,1,3-BENZOXADIAZOL-4-AMINE'>3Y7</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Legumain Legumain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.34 3.4.22.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lub OCA], [https://pdbe.org/5lub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lub RCSB], [https://www.ebi.ac.uk/pdbsum/5lub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lub ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lub OCA], [http://pdbe.org/5lub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lub RCSB], [http://www.ebi.ac.uk/pdbsum/5lub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lub ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
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[https://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Legumain]]
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[[Category: Homo sapiens]]
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[[Category: Brandstetter, H]]
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[[Category: Large Structures]]
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[[Category: Dall, E]]
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[[Category: Brandstetter H]]
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[[Category: Ye, K]]
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[[Category: Dall E]]
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[[Category: Allosteric inhibitor]]
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[[Category: Ye K]]
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[[Category: Alzheimer's disease]]
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[[Category: Asparaginyl endopeptidase]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of human legumain (AEP) in complex with compound 11

PDB ID 5lub

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