Crystallin

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<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystalline, [[2g98]]'>
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<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystallin, [[2g98]]'>
== Function ==
== Function ==
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'''Crystalline''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystalline are named according to the order they are eluted by gel filtration. δ-crystalline is found in avian and reptilian lenses.<ref>PMID:12729747</ref>
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'''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. '''α-, β-, γ-, δ-crystallin''' are named according to the order they are eluted by gel filtration.
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*'''Alpha crystallin''' has chaperone-like properties like the ability to prevent precipitation of denatured proteins<ref>PMID:15575808</ref>. See [[Alpha crystallin]].
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*'''Gamma crystallin''' is found mainly in the nuclear region of the lens<ref>PMID:26116913</ref>.
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*.''' δ-crystallin''' is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses<ref>PMID:6369110</ref>.
== Disease ==
== Disease ==
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Several human cataracts have been linked to mutations in γ-D-crystalline<ref>PMID:11371638</ref>.
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Mutations in α-A-crystallin and α-B-crystallin can cause myopathy<ref>PMID:12565801</ref>. Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>.
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</StructureSection>
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== 3D Structures of Crystalline ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== 3D Structures of Crystallin ==
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[[Crystallin 3D structures]]
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[[2g98]] - hγ-D-crystalline – human<br />
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</StructureSection>
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[[1h4a]] - hγ-D-crystalline (mutant)<br />
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[[1elp]] - γ-D-crystalline – bovine<br />
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[[1auw]] - δ-2-crystalline (mutant) - duck
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== References ==
== References ==

Current revision

human γ-D-crystallin, 2g98

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References

  1. ↑ Augusteyn RC. alpha-crystallin: a review of its structure and function. Clin Exp Optom. 2004 Nov;87(6):356-66. doi: 10.1111/j.1444-0938.2004.tb03095.x. PMID:15575808 doi:http://dx.doi.org/10.1111/j.1444-0938.2004.tb03095.x
  2. ↑ Vendra VP, Khan I, Chandani S, Muniyandi A, Balasubramanian D. Gamma crystallins of the human eye lens. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):333-43. PMID:26116913 doi:10.1016/j.bbagen.2015.06.007
  3. ↑ Piatigorsky J. Delta crystallins and their nucleic acids. Mol Cell Biochem. 1984;59(1-2):33-56. PMID:6369110 doi:10.1007/BF00231304
  4. ↑ Horwitz J. Alpha-crystallin. Exp Eye Res. 2003 Feb;76(2):145-53. doi: 10.1016/s0014-4835(02)00278-6. PMID:12565801 doi:http://dx.doi.org/10.1016/s0014-4835(02)00278-6
  5. ↑ Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:http://dx.doi.org/10.1073/pnas.101124798

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