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5v9i

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(New page: '''Unreleased structure''' The entry 5v9i is ON HOLD Authors: Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., W...)
Current revision (13:44, 4 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5v9i is ON HOLD
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==Crystal structure of catalytic domain of G9a with MS0105==
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<StructureSection load='5v9i' size='340' side='right'caption='[[5v9i]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5v9i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V9I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=90P:N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine'>90P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v9i OCA], [https://pdbe.org/5v9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v9i RCSB], [https://www.ebi.ac.uk/pdbsum/5v9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v9i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
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Authors: Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Wu, H., Brown, P.J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Crystal structure of catalytic domain of G9a with UNC3644
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Arrowsmith, C.H]]
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__TOC__
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[[Category: Dong, A]]
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</StructureSection>
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[[Category: Brown, P.J]]
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[[Category: Homo sapiens]]
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[[Category: Zeng, H]]
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[[Category: Large Structures]]
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[[Category: Xiong, Y]]
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[[Category: Arrowsmith CH]]
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[[Category: Babault, N]]
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[[Category: Babault N]]
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[[Category: Edwards, A.M]]
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[[Category: Bountra C]]
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[[Category: Walker, J.R]]
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[[Category: Brown PJ]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Dong A]]
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[[Category: Liu, J]]
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[[Category: Edwards AM]]
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[[Category: Wu, H]]
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[[Category: Jin J]]
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[[Category: Jin, J]]
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[[Category: Liu J]]
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[[Category: Bountra, C]]
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[[Category: Walker JR]]
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[[Category: Wu H]]
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[[Category: Xiong Y]]
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[[Category: Zeng H]]

Current revision

Crystal structure of catalytic domain of G9a with MS0105

PDB ID 5v9i

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