5vbl

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(New page: '''Unreleased structure''' The entry 5vbl is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (16:50, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5vbl is ON HOLD
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==Structure of apelin receptor in complex with agonist peptide==
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<StructureSection load='5vbl' size='340' side='right'caption='[[5vbl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VBL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=200:4-CHLORO-L-PHENYLALANINE'>200</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HRG:L-HOMOARGININE'>HRG</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OIC:OCTAHYDROINDOLE-2-CARBOXYLIC+ACID'>OIC</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbl OCA], [https://pdbe.org/5vbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbl RCSB], [https://www.ebi.ac.uk/pdbsum/5vbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.[https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela, each with different isoforms diversified by length and amino acid sequence. Here we report the 2.6-A resolution crystal structure of human APJR in complex with a designed 17-amino-acid apelin mimetic peptide agonist. The structure reveals that the peptide agonist adopts a lactam constrained curved two-site ligand binding mode. Combined with mutation analysis and molecular dynamics simulations with apelin-13 binding to the wild-type APJR, this structure provides a mechanistic understanding of apelin recognition and binding specificity. Comparison of this structure with that of other peptide receptors suggests that endogenous peptide ligands with a high degree of conformational flexibility may bind and modulate the receptors via a similar two-site binding mechanism.
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Authors:
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Structural Basis for Apelin Control of the Human Apelin Receptor.,Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F Structure. 2017 Jun 6;25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017, May 18. PMID:28528775<ref>PMID:28528775</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5vbl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Clostridium pasteurianum]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Han GW]]
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[[Category: Hanson MA]]
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[[Category: Hu LA]]
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[[Category: Li C]]
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[[Category: Li X]]
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[[Category: Ma X]]
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[[Category: Ma Y]]
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[[Category: Shen Y]]
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[[Category: Sickmier EA]]
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[[Category: Song Y]]
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[[Category: Stevems RC]]
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[[Category: Swaminath G]]
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[[Category: Xu F]]
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[[Category: Yue Y]]
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[[Category: Zhang M]]
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[[Category: Zhang Q]]
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[[Category: Zhao S]]
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[[Category: Zhong W]]
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[[Category: Zhou Q]]

Current revision

Structure of apelin receptor in complex with agonist peptide

PDB ID 5vbl

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