5ly6
From Proteopedia
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==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A== | ==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A== | ||
| - | < | + | <SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution|resolution]] 4.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LY6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [https://pdbe.org/5ly6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5ly6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ly6" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Cytolysin 3D structures|Cytolysin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptococcus pneumoniae D39]] |
| - | [[Category: | + | [[Category: D'Imprima E]] |
| - | [[Category: | + | [[Category: Kuehlbrandt W]] |
| - | [[Category: | + | [[Category: Mills DJ]] |
| - | [[Category: | + | [[Category: Neuhaus A]] |
| - | [[Category: | + | [[Category: Yildiz O]] |
| - | [[Category: | + | [[Category: Van Pee K]] |
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Current revision
CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A
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