5j12

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==Cytokine receptor complex==
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==Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha==
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<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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<StructureSection load='5j12' size='340' side='right'caption='[[5j12]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [http://pdbe.org/5j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [http://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [https://pdbe.org/5j12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [https://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref> [[http://www.uniprot.org/uniprot/CRLF2_HUMAN CRLF2_HUMAN]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.<ref>PMID:11418668</ref> [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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[https://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>
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==See Also==
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Savvides, S N]]
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[[Category: Homo sapiens]]
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[[Category: Verstraete, K]]
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[[Category: Large Structures]]
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[[Category: Cytokine inflammation tslp signaling complex]]
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[[Category: Mus musculus]]
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[[Category: Signaling protein]]
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[[Category: Savvides SN]]
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[[Category: Verstraete K]]

Current revision

Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha

PDB ID 5j12

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