Cytochrome c oxidase

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== Function ==
== Function ==
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'''Cytochrome c oxidase''' (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. <ref>PMID:7652554</ref>
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'''Cytochrome c oxidase''' (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. <ref>PMID:7652554</ref>
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*'''Ba3-type cytochrome c oxidase''' substrate is cytochrome c552 <ref>PMID:10775261</ref>.
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See also [[Hemeproteins]].
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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Mammalian CcO is composed of <scene name='46/466466/Cv/2'>13 subunits</scene>, <scene name='46/466466/Cv/4'>2 hemes, two copper centers</scene>, and cytochrome a and a3. The fully oxidized form of <scene name='46/466466/Cv/7'>CcO active site shows the heme, Cu+2 ion and an O2</scene> molecule. <scene name='46/466466/Cv/8'>Second heme binding site</scene>. <ref>PMID:9624044</ref> Bacterial CcO is composed of 2 subunits.
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Mammalian CcO is composed of <scene name='46/466466/Cv/9'>13 subunits</scene>, <scene name='46/466466/Cv/10'>2 hemes, two copper centers</scene>, and cytochrome a and a3. The fully oxidized form of <scene name='46/466466/Cv/11'>CcO active site shows the heme, Cu+2 ion and an O2</scene> molecule. <scene name='46/466466/Cv/12'>Second heme binding site</scene>. <ref>PMID:9624044</ref> Bacterial CcO is composed of 2 subunits.
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</StructureSection>
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== 3D Structures of Cytochrome c oxidase ==
== 3D Structures of Cytochrome c oxidase ==
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[[Cytochrome c oxidase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Mammalian CcO
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**[[1occ]], [[2occ]], [[1v54]], [[2dyr]], [[2zxw]], [[3abl]], [[3abm]], [[3asn]], [[3aso]], [[3x2q]] – bCcO oxidized – bovine<br />
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**[[2eil]], [[2ein]] - bCcO oxidized + meta<br />
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**[[1ocr]], [[1v55]], [[2eij]], [[3ag1]] – bCcO reduced<br />
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**[[2eik]], [[2eim]], [[5b1b]] - bCcO reduced + metal<br />
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**[[3abk]], [[3ag3]] - bCcO reduced + NO<br />
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**[[3ag2]] - bCcO reduced + CO<br />
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**[[3ag4]] - bCcO reduced + CN<br />
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**[[1ocz]] – bCcO + N3<br />
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**[[2y69]], [[3wg7]] – bCcO + O2<br />
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**[[1oco]], [[5b3s]] - bCcO + CO<br />
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**[[2dys]] – bCcO + lipids<br />
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**[[5luf]] – bCcO in respirasome – Cryo EM<br />
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**[[2ybb]] – bCcO + cytochrome bc1 complex + NADH-quinone oxidoreductase – Cryo EM<br />
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**[[5iy5]] – bCcO + cytochrome c<br />
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*Bacterial CcO
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**[[1ar1]], [[1qle]] – PdCcO + antibody – ''Paracoccus denitrificans''<br />
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**[[3ehb]] – PdCcO (mutant) <br />
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**[[3hb3]] - PdCcO<br />
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**[[1m56]] – RsCcO – ''Rhodoacter sphaeroides''<br />
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**[[1m57]] – RsCcO (mutant) <br />
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**[[2gsm]] – RsCcO subunit I+II<br />
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**[[3fye]] - RsCcO subunit I+II reduced<br />
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**[[3om3]], [[3oma]], [[3omi]], [[3omn]] - RsCcO subunit I+II reduced (mutant) <br />
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**[[3fyi]] - RsCcO subunit I+II reduced + CN<br />
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**[[3dtu]] - RsCcO subunit I+II + deoxycholic acid<br />
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**[[1xme]], [[2qpd]], [[2qpe]], [[3bvd]], [[3s8f]], [[3s33]], [[3s38]], [[3s39]], [[3s3a]], [[3s3b]], [[3s3c]], [[3s3d]] – TtCcO – ''Thermus thermophilus''<br />
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**[[3eh3]], [[3eh4]], [[3eh5]] – TtCcO reduced<br />
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**[[3qjq]], [[3qjr]], [[3qjs]], [[3qjt]], [[3qju]], [[3qjv]] – TtCcO + CO<br />
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**[[3s8g]], [[4fa7]], [[4faa]] – TtCcO (mutant) <br />
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**[[4n4y]] - TtCcO (mutant) + H2O2<br />
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**[[2lln]] – TtCcO subunit II - NMR<br />
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**[[2yev]] - TtCcO subunit I,IIC,III,IV <br />
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**[[4g70]], [[4g71]], [[4g72]], [[4g7q]], [[4g7r]], [[4g7s]], [[4gp4]], [[4gp5]], [[4gp8]] - TtCcO subunit I (mutant),II,IIA <br />
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**[[2fwl]] – TtCcO subunit II + cytochrome C552<br />
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**[[3mk7]], [[5djq]] – CcO + peptide – ''Pseudomonas stutzeri''<br />
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**[[1w2l]] - CcO subunit II – ''Rhodothermus marinus''<br />
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**[[4txv]] - CcO subunit II + TlpA – ''Bradyrhizobium diazoefficiens''<br />
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**[[4w9z]] - CcO subunit II – ''Bradyhisobium diazoefficiens''<br />
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*Ba3-type CcO
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**[[1ehk]] – TtCcO subunits I,II,IIA<br />
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}}
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== References ==
== References ==

Current revision

Bovine cytochrome c oxidase. Homodimer with 13 subunits (PDB entry 2occ)

Drag the structure with the mouse to rotate

References

  1. ↑ Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science. 1995 Aug 25;269(5227):1069-74. PMID:7652554
  2. ↑ Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME. Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. PMID:10775261 doi:10.1093/emboj/19.8.1766
  3. ↑ Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T. Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044

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