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5nkp

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'''Unreleased structure'''
 
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The entry 5nkp is ON HOLD
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==Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide==
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<StructureSection load='5nkp' size='340' side='right'caption='[[5nkp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nkp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NKP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nkp OCA], [https://pdbe.org/5nkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nkp RCSB], [https://www.ebi.ac.uk/pdbsum/5nkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nkp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Pseudohypoaldosteronism type 2D. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.<ref>PMID:14528312</ref> <ref>PMID:23387299</ref> <ref>PMID:23453970</ref> <ref>PMID:23665031</ref> <ref>PMID:23576762</ref> <ref>PMID:22406640</ref>
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Authors: Chen, Z., Sorrell, F.J., Pinkas, D.M., Williams, E., Mathea, S., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
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==See Also==
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*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
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Description: Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Bullock, A]]
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__TOC__
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[[Category: Goubin, S]]
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</StructureSection>
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[[Category: Mathea, S]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Large Structures]]
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[[Category: Williams, E]]
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[[Category: Arrowsmith CH]]
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[[Category: Von Delft, F]]
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[[Category: Bountra C]]
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[[Category: Pinkas, D.M]]
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[[Category: Bullock A]]
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[[Category: Edwards, A.M]]
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[[Category: Burgess-Brown N]]
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[[Category: Chen, Z]]
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[[Category: Chen Z]]
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[[Category: Bountra, C]]
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[[Category: Edwards AM]]
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[[Category: Sorrell, F.J]]
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[[Category: Goubin S]]
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[[Category: Mathea S]]
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[[Category: Pinkas DM]]
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[[Category: Sorrell FJ]]
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[[Category: Williams E]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide

PDB ID 5nkp

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OCA

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