5nl2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5nl2 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures)
Current revision (13:04, 15 November 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5nl2 is ON HOLD until Paper Publication
+
==cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution.==
 +
<SX load='5nl2' size='340' side='right' viewer='molstar' caption='[[5nl2]], [[Resolution|resolution]] 6.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5nl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NL2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.6&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nl2 OCA], [https://pdbe.org/5nl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nl2 RCSB], [https://www.ebi.ac.uk/pdbsum/5nl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nl2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ANO1_MOUSE ANO1_MOUSE] Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.<ref>PMID:18585372</ref> <ref>PMID:18724360</ref> <ref>PMID:21908539</ref> <ref>PMID:22002868</ref> <ref>PMID:22075693</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The calcium-activated chloride channel TMEM16A is a member of a conserved protein family that comprises ion channels and lipid scramblases. Although the structure of the scramblase nhTMEM16 has defined the architecture of the family, it was unknown how a channel has adapted to cope with its distinct functional properties. Here we have addressed this question by the structure determination of mouse TMEM16A by cryo-electron microscopy and a complementary functional characterization. The protein shows a similar organization to nhTMEM16, except for changes at the site of catalysis. There, the conformation of transmembrane helices constituting a membrane-spanning furrow that provides a path for lipids in scramblases has changed to form an enclosed aqueous pore that is largely shielded from the membrane. Our study thus reveals the structural basis of anion conduction in a TMEM16 channel and it defines the foundation for the diverse functional behavior in the TMEM16 family.
-
Authors:
+
Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.,Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R Elife. 2017 May 31;6. pii: e26232. doi: 10.7554/eLife.26232. PMID:28561733<ref>PMID:28561733</ref>
-
Description:
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
 +
<div class="pdbe-citations 5nl2" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Anoctamin 3D structures|Anoctamin 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</SX>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Brunner JD]]
 +
[[Category: Dutzler R]]
 +
[[Category: Kalienkova V]]
 +
[[Category: Lam KM]]
 +
[[Category: Neldner Y]]
 +
[[Category: Paulino C]]
 +
[[Category: Schenck S]]

Current revision

cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution.

5nl2, resolution 6.60Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5nl2"
Personal tools