5pzw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[5-[(3-chlorophenyl)sulfonylcarbamoylamino]pentyl]urea== | |
| + | <StructureSection load='5pzw' size='340' side='right'caption='[[5pzw]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5pzw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PZW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=94J:N,N-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)'>94J</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzw OCA], [https://pdbe.org/5pzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pzw RCSB], [https://www.ebi.ac.uk/pdbsum/5pzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Burley | + | __TOC__ |
| - | [[Category: Yang | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alker A]] | ||
| + | [[Category: Banner D]] | ||
| + | [[Category: Benz J]] | ||
| + | [[Category: Burley SK]] | ||
| + | [[Category: Joseph C]] | ||
| + | [[Category: Kuhn B]] | ||
| + | [[Category: Rudolph MG]] | ||
| + | [[Category: Ruf A]] | ||
| + | [[Category: Shao C]] | ||
| + | [[Category: Tetaz T]] | ||
| + | [[Category: Yang H]] | ||
Current revision
Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[5-[(3-chlorophenyl)sulfonylcarbamoylamino]pentyl]urea
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Categories: Homo sapiens | Large Structures | Alker A | Banner D | Benz J | Burley SK | Joseph C | Kuhn B | Rudolph MG | Ruf A | Shao C | Tetaz T | Yang H
