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5v7z

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'''Unreleased structure'''
 
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The entry 5v7z is ON HOLD
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==SSNMR Structure of the Human RIP1/RIP3 Necrosome==
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<StructureSection load='5v7z' size='340' side='right'caption='[[5v7z]]' scene=''>
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Authors: Mompean, M., Li, W., Li, J., Laage, S., Siemer, A.B., Wu, H., McDermott, A.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5v7z]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V7Z FirstGlance]. <br>
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Description: SSNMR Structure of the Human RIP1/RIP3 Necrosome
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7z OCA], [https://pdbe.org/5v7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v7z RCSB], [https://www.ebi.ac.uk/pdbsum/5v7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7z ProSAT]</span></td></tr>
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[[Category: Mompean, M]]
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</table>
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[[Category: Li, J]]
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== Function ==
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[[Category: Li, W]]
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[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
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[[Category: Siemer, A.B]]
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== References ==
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[[Category: Laage, S]]
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<references/>
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[[Category: Mcdermott, A.E]]
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__TOC__
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[[Category: Wu, H]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Laage S]]
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[[Category: Li J]]
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[[Category: Li W]]
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[[Category: McDermott AE]]
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[[Category: Mompean M]]
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[[Category: Siemer AB]]
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[[Category: Wu H]]

Current revision

SSNMR Structure of the Human RIP1/RIP3 Necrosome

PDB ID 5v7z

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