5vei

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(New page: '''Unreleased structure''' The entry 5vei is ON HOLD Authors: Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Struct...)
Current revision (13:47, 4 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5vei is ON HOLD
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==Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2==
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<StructureSection load='5vei' size='340' side='right'caption='[[5vei]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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Authors: Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vei]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4igz 4igz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VEI FirstGlance]. <br>
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Description: Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vei OCA], [https://pdbe.org/5vei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vei RCSB], [https://www.ebi.ac.uk/pdbsum/5vei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vei ProSAT]</span></td></tr>
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[[Category: Huang, H]]
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</table>
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[[Category: Sidhu, S.S]]
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== Function ==
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[[Category: Liu, K]]
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[https://www.uniprot.org/uniprot/SRBS2_HUMAN SRBS2_HUMAN] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.<ref>PMID:9211900</ref> <ref>PMID:12475393</ref>
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[[Category: Min, J]]
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== References ==
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[[Category: Edwards, A.M]]
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<references/>
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[[Category: Gu, J]]
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__TOC__
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[[Category: Structural Genomics Consortium (Sgc)]]
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</StructureSection>
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[[Category: Liu, Y]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Tempel, W]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Gu J]]
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[[Category: Huang H]]
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[[Category: Liu K]]
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[[Category: Liu Y]]
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[[Category: Min J]]
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[[Category: Sidhu SS]]
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[[Category: Tempel W]]

Current revision

Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2

PDB ID 5vei

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