5vei
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2== | |
- | + | <StructureSection load='5vei' size='340' side='right'caption='[[5vei]], [[Resolution|resolution]] 1.33Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5vei]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4igz 4igz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VEI FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33Å</td></tr> | |
- | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
- | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vei OCA], [https://pdbe.org/5vei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vei RCSB], [https://www.ebi.ac.uk/pdbsum/5vei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vei ProSAT]</span></td></tr> |
- | [[Category: | + | </table> |
- | [[Category: | + | == Function == |
- | [[Category: | + | [https://www.uniprot.org/uniprot/SRBS2_HUMAN SRBS2_HUMAN] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.<ref>PMID:9211900</ref> <ref>PMID:12475393</ref> |
- | [[Category: | + | == References == |
- | [[Category: | + | <references/> |
- | [[Category: | + | __TOC__ |
- | [[Category: | + | </StructureSection> |
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: Tempel | + | [[Category: Arrowsmith CH]] |
+ | [[Category: Bountra C]] | ||
+ | [[Category: Edwards AM]] | ||
+ | [[Category: Gu J]] | ||
+ | [[Category: Huang H]] | ||
+ | [[Category: Liu K]] | ||
+ | [[Category: Liu Y]] | ||
+ | [[Category: Min J]] | ||
+ | [[Category: Sidhu SS]] | ||
+ | [[Category: Tempel W]] |
Current revision
Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | Gu J | Huang H | Liu K | Liu Y | Min J | Sidhu SS | Tempel W