5xep

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'''Unreleased structure'''
 
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The entry 5xep is ON HOLD until Paper Publication
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==Crystal structure of BRP39, a chitinase-like protein, at 2.6 Angstorm resolution==
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<StructureSection load='5xep' size='340' side='right'caption='[[5xep]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xep]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XEP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xep OCA], [https://pdbe.org/5xep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xep RCSB], [https://www.ebi.ac.uk/pdbsum/5xep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xep ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CH3L1_MOUSE CH3L1_MOUSE] Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.<ref>PMID:16472595</ref> <ref>PMID:19041398</ref> <ref>PMID:19414556</ref> <ref>PMID:20558631</ref> <ref>PMID:21546314</ref> <ref>PMID:22817986</ref>
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Authors: Mohanty, A.K., Fisher, A.J., Choudhary, S., Kaushik, J.K.
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==See Also==
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*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
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Description: Crystal structure of BRP39, a chitinase-like protein, at 2.6 Angstorm resolution
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Mohanty, A.K]]
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__TOC__
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[[Category: Fisher, A.J]]
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</StructureSection>
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[[Category: Kaushik, J.K]]
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[[Category: Large Structures]]
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[[Category: Choudhary, S]]
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[[Category: Mus musculus]]
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[[Category: Choudhary S]]
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[[Category: Fisher AJ]]
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[[Category: Kaushik JK]]
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[[Category: Mohanty AK]]

Current revision

Crystal structure of BRP39, a chitinase-like protein, at 2.6 Angstorm resolution

PDB ID 5xep

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