5k89

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==Crystal Structure of Human Calcium-Bound S100A1==
==Crystal Structure of Human Calcium-Bound S100A1==
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<StructureSection load='5k89' size='340' side='right' caption='[[5k89]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5k89' size='340' side='right'caption='[[5k89]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.249&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [http://pdbe.org/5k89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [http://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [https://pdbe.org/5k89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [https://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
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[https://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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S100A1 is a member of the S100 family of Ca(2+)-binding proteins and regulates several cellular processes, including those involved in Ca(2+) signaling and cardiac and skeletal muscle function. In Alzheimer's disease, brain S100A1 is overexpressed and gives rise to disease pathologies, making it a potential therapeutic target. The 2.25 A resolution crystal structure of Ca(2+)-S100A1 is solved here and is compared with the structures of other S100 proteins, most notably S100B, which is a highly homologous S100-family member that is implicated in the progression of malignant melanoma. The observed structural differences in S100A1 versus S100B provide insights regarding target protein-binding specificity and for targeting these two S100 proteins in human diseases using structure-based drug-design approaches.
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X-ray crystal structure of human calcium-bound S100A1.,Melville Z, Aligholizadeh E, McKnight LE, Weber DJ, Pozharski E, Weber DJ Acta Crystallogr F Struct Biol Commun. 2017 Apr 1;73(Pt 4):215-221. doi:, 10.1107/S2053230X17003983. Epub 2017 Mar 22. PMID:28368280<ref>PMID:28368280</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5k89" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aligholizadeh, E]]
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[[Category: Homo sapiens]]
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[[Category: McKnight, L E]]
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[[Category: Large Structures]]
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[[Category: Melville, Z]]
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[[Category: Aligholizadeh E]]
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[[Category: Pozharski, E]]
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[[Category: McKnight LE]]
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[[Category: Weber, D]]
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[[Category: Melville Z]]
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[[Category: Weber, D J]]
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[[Category: Pozharski E]]
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[[Category: Calcium]]
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[[Category: Weber D]]
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[[Category: Metal binding protein]]
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[[Category: Weber DJ]]
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[[Category: S100]]
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[[Category: S100a1]]
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Current revision

Crystal Structure of Human Calcium-Bound S100A1

PDB ID 5k89

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