5tbx
From Proteopedia
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==hnRNP A18 RNA Recognition Motif== | ==hnRNP A18 RNA Recognition Motif== | ||
| - | <StructureSection load='5tbx' size='340' side='right' caption='[[5tbx]], [[Resolution|resolution]] 1.77Å' scene=''> | + | <StructureSection load='5tbx' size='340' side='right'caption='[[5tbx]], [[Resolution|resolution]] 1.77Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TBX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.767Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [https://pdbe.org/5tbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [https://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Aligholizadeh E]] |
| - | [[Category: | + | [[Category: Coburn KM]] |
| - | [[Category: | + | [[Category: Melville Z]] |
| - | [[Category: | + | [[Category: Roth BM]] |
| - | [[Category: | + | [[Category: Varney KM]] |
| - | [[Category: | + | [[Category: Weber DJ]] |
Current revision
hnRNP A18 RNA Recognition Motif
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