Dethiobiotin synthetase

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<StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'>
<StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'>
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'''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref>
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'''Dethiobiotin synthetase''' (DTBS) or '''ATP-depenent dethiobiotin synthetase''' catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref>
== Structural highlights ==
== Structural highlights ==
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The <scene name='49/493028/Cv/4'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref>
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The <scene name='49/493028/Cv/5'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref>
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</StructureSection>
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==3D dethiobiotin synthetase==
==3D dethiobiotin synthetase==
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[[Dethiobiotin synthetase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*DTBS
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**[[1dbs]], [[1dts]], [[1byi]] – EcDTBS – ''Escherichia coli''<br />
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**[[2qmo]] – HpDTBS – ''Helicobacter pylori''<br />
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**[[3fgn]] – MtDTBS – ''Mycobacterium tuberculosis''<br />
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**[[3of5]] – DTBS – ''Francicella tularensis''
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*DTBS binary complex
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**[[3fmf]] – MtDTBS + DAN<br />
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**[[4wop]] - MtDTBS + CTP<br />
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**[[3fmi]] – MtDTBS + aminopelargonic acid<br />
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**[[1dad]] – EcDTBS + ADP<BR />
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**[[1dae]] - EcDTBS + nonanedioate derivative<br />
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**[[1dai]] - EcDTBS + DAN
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*DTBS ternary complex
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**[[3qxc]] - HpDTBS + Mg + ATP<BR />
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**[[1daf]] - EcDTBS + DAN + ADP<BR />
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**[[1dag]] - EcDTBS + DAN + ATP derivative<br />
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**[[3qxj]] - HpDTBS + Mg + ATP<BR />
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**[[3qxs]] - HpDTBS + Mg + phosphoaminophosphonic acid
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*DTBS quaternary complex
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**[[1dah]] - EcDTBS + DAN + Mn + ATP derivative<br />
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**[[1bs1]] - EcDTBS + DTB + Mg + ADP<BR />
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**[[1a82]] - EcDTBS + DAN + Mg + ATP<BR />
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**[[3fpa]] - MtDTBS + DTB + Mg + phosphate <br />
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**[[3mle]] - HpDTBS + Mg + phosphate + ADP<BR />
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**[[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR />
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*DTBS higher complexes
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**[[1dam]] - EcDTBS + DTB + Mg + phosphate + ADP<BR />
 
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**[[1dak]] - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP<BR />
 
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**[[3qxh]] - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP<BR />
 
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**[[3qxx]] - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP<BR />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry 1a82)

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References

  1. ↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
  2. ↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910

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Michal Harel, Alexander Berchansky

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