1qkl

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==hRPABC14.4, essential subunit of human RNA polymerases I, II and III==
==hRPABC14.4, essential subunit of human RNA polymerases I, II and III==
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<StructureSection load='1qkl' size='340' side='right' caption='[[1qkl]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
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<StructureSection load='1qkl' size='340' side='right'caption='[[1qkl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1qkl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1qkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKL FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkl OCA], [http://pdbe.org/1qkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qkl RCSB], [http://www.ebi.ac.uk/pdbsum/1qkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkl OCA], [https://pdbe.org/1qkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qkl RCSB], [https://www.ebi.ac.uk/pdbsum/1qkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPAB2_HUMAN RPAB2_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).<ref>PMID:9852112</ref>
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[https://www.uniprot.org/uniprot/RPAB2_HUMAN RPAB2_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).<ref>PMID:9852112</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkl_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Homo sapiens]]
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[[Category: Gaskell, A G]]
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[[Category: Large Structures]]
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[[Category: Gilbert, D]]
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[[Category: Del Rio-Portilla F]]
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[[Category: Ladias, J A.A]]
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[[Category: Gaskell AG]]
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[[Category: Rio-Portilla, F Del]]
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[[Category: Gilbert D]]
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[[Category: Wagner, G]]
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[[Category: Ladias JAA]]
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[[Category: Rna polymerase]]
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[[Category: Wagner G]]
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[[Category: Transcription]]
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Current revision

hRPABC14.4, essential subunit of human RNA polymerases I, II and III

PDB ID 1qkl

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