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5fxg

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==GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION==
==GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION==
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<StructureSection load='5fxg' size='340' side='right' caption='[[5fxg]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
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<SX load='5fxg' size='340' side='right' viewer='molstar' caption='[[5fxg]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fxg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FXG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fxg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FXG FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fxh|5fxh]], [[5fxi|5fxi]], [[5fxj|5fxj]], [[5fxk|5fxk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxg OCA], [http://pdbe.org/5fxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fxg RCSB], [http://www.ebi.ac.uk/pdbsum/5fxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fxg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxg OCA], [https://pdbe.org/5fxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fxg RCSB], [https://www.ebi.ac.uk/pdbsum/5fxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fxg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
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[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fxg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fxg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Diaz-Avalos, R]]
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[[Category: Large Structures]]
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[[Category: Furukawa, H]]
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[[Category: Rattus norvegicus]]
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[[Category: Grant, T]]
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[[Category: Diaz-Avalos R]]
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[[Category: Grigorieff, N]]
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[[Category: Furukawa H]]
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[[Category: Karakas, E]]
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[[Category: Grant T]]
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[[Category: Simorowski, N]]
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[[Category: Grigorieff N]]
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[[Category: Tajima, N]]
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[[Category: Karakas E]]
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[[Category: Glun1]]
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[[Category: Simorowski N]]
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[[Category: Glun2b]]
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[[Category: Tajima N]]
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[[Category: Glutamate receptor]]
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[[Category: Ion channel]]
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[[Category: Nmda receptor]]
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[[Category: Signaling protein]]
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[[Category: Transport protein]]
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Current revision

GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION

5fxg, resolution 6.80Å

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OCA

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