5gg9

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==Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-GTP, 8-oxo-GMP and pyrophosphate==
==Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-GTP, 8-oxo-GMP and pyrophosphate==
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<StructureSection load='5gg9' size='340' side='right' caption='[[5gg9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5gg9' size='340' side='right'caption='[[5gg9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gg9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GG9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GG9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8GM:[(2R,3S,4R,5R)-5-[2-AZANYL-6,8-BIS(OXIDANYLIDENE)-1,7-DIHYDROPURIN-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>8GM</scene>, <scene name='pdbligand=8GT:8-OXO-GUANOSINE-5-TRIPHOSPHATE'>8GT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gg5|5gg5]], [[5gg6|5gg6]], [[5gg7|5gg7]], [[5gg8|5gg8]], [[5gga|5gga]], [[5ggb|5ggb]], [[5ggc|5ggc]], [[5ggd|5ggd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8GM:[(2R,3S,4R,5R)-5-[2-AZANYL-6,8-BIS(OXIDANYLIDENE)-1,7-DIHYDROPURIN-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>8GM</scene>, <scene name='pdbligand=8GT:8-OXO-GUANOSINE-5-TRIPHOSPHATE'>8GT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gg9 OCA], [http://pdbe.org/5gg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gg9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gg9 OCA], [https://pdbe.org/5gg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gg9 RCSB], [https://www.ebi.ac.uk/pdbsum/5gg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gg9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MUTT1_MYCS2 MUTT1_MYCS2] Catalyzes the conversion of 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP (PubMed:16585780, PubMed:28375146). At high enzyme concentrations, can also catalyze the conversion of 8-oxo-dGDP to 8-oxo-dGMP, and 8-oxo-GDP to 8-oxo-GMP (PubMed:28375146). In addition, catalyzes the hydrolysis of the diadenosine polyphosphates diadenosine hexaphosphate (Ap6A), diadenosine pentaphosphate (Ap5A) and diadenosine tetraphosphate (Ap4A) (PubMed:28705712).<ref>PMID:16585780</ref> <ref>PMID:28375146</ref> <ref>PMID:28705712</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5gg9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5gg9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arif, S M]]
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[[Category: Large Structures]]
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[[Category: Patil, A G]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Varshney, U]]
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[[Category: Arif SM]]
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[[Category: Vijayan, M]]
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[[Category: Patil AG]]
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[[Category: 8-oxo-guanine nucleotide]]
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[[Category: Varshney U]]
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[[Category: Binding sites at intermolecular interface]]
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[[Category: Vijayan M]]
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[[Category: Enzyme action]]
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[[Category: Histidine phosphatase domain]]
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[[Category: Hydrolase]]
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[[Category: Nudix enzyme]]
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[[Category: Sanitization of nucleotide pool]]
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Current revision

Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-GTP, 8-oxo-GMP and pyrophosphate

PDB ID 5gg9

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