2mrz

<StructureSection load='2mrz' size='340' side='right' caption='[[2mrz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2mrz]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MRZ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mrz OCA], [http://pdbe.org/2mrz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mrz RCSB], [http://www.ebi.ac.uk/pdbsum/2mrz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mrz ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Human centromeric alpha-satellite DNA is composed of tandem arrays of two types of 171 bp monomers; type A and type B. The differences between these types are concentrated in a 17 bp region of the monomer called the A/B box. Here, we have determined the solution structure of the C-rich strand of the two main variants of the human alpha-satellite A box. We show that, under acidic conditions, the C-rich strands of two A boxes self-recognize and form a head-to-tail dimeric i-motif stabilized by four intercalated hemi-protonated C:C+ base pairs. Interestingly, the stack of C:C+ base pairs is capped by T:T and Hoogsteen A:T base pairs. The two main variants of the A box adopt a similar three-dimensional structure, although the residues involved in the formation of the i-motif core are different in each case. Together with previous studies showing that the B box (known as the CENP-B box) also forms dimeric i-motif structures, our finding of this non-canonical structure in the A box shows that centromeric alpha satellites in all human chromosomes are able to form i-motifs, which consequently raises the possibility that these structures may play a role in the structural organization of the centromere.

Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs.,Garavis M, Escaja N, Gabelica V, Villasante A, Gonzalez C Chemistry. 2015 May 27. doi: 10.1002/chem.201500448. PMID:26013031<ref>PMID:26013031</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2mrz" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Escaja, N]]

[[Category: Gabelica, V]]

[[Category: Garavis, M]]

[[Category: Gonzalez, C]]

[[Category: Villasante, A]]

[[Category: Centromere]]

[[Category: Dna]]

[[Category: Self-recognition]]