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5uhe

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==Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-AAP1==
==Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-AAP1==
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<StructureSection load='5uhe' size='340' side='right' caption='[[5uhe]], [[Resolution|resolution]] 4.04&Aring;' scene=''>
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<StructureSection load='5uhe' size='340' side='right'caption='[[5uhe]], [[Resolution|resolution]] 4.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uhe]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UHE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uhe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=88G:NALPHA-(BENZENECARBONYL)-N-(2-METHYLPHENYL)-D-PHENYLALANINAMIDE'>88G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.039&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uh6|5uh6]], [[5uh7|5uh7]], [[5uh8|5uh8]], [[5uh9|5uh9]], [[5uha|5uha]], [[5uhb|5uhb]], [[5uhc|5uhc]], [[5uhd|5uhd]], [[5uhf|5uhf]], [[5uhg|5uhg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=88G:NALPHA-(BENZENECARBONYL)-N-(2-METHYLPHENYL)-D-PHENYLALANINAMIDE'>88G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhe OCA], [https://pdbe.org/5uhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uhe RCSB], [https://www.ebi.ac.uk/pdbsum/5uhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhe OCA], [http://pdbe.org/5uhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uhe RCSB], [http://www.ebi.ac.uk/pdbsum/5uhe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhe ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPOZ_MYCTU RPOZ_MYCTU]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOA_MYCTU RPOA_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00059]<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOC_MYCTU RPOC_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322]<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOB_MYCTU RPOB_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [[http://www.uniprot.org/uniprot/SIGA_MYCTU SIGA_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable).<ref>PMID:12354223</ref> <ref>PMID:20729364</ref> <ref>PMID:22570422</ref>
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[https://www.uniprot.org/uniprot/RPOA_MYCTU RPOA_MYCTU] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00059]<ref>PMID:22570422</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5uhe" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5uhe" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Das, K]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Ebright, R H]]
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[[Category: Das K]]
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[[Category: Feng, Y]]
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[[Category: Ebright RH]]
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[[Category: Lin, W]]
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[[Category: Feng Y]]
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[[Category: Dna]]
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[[Category: Lin W]]
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[[Category: Rna]]
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[[Category: Rna polymerase complex]]
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[[Category: Transcription]]
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[[Category: Transcription-dna-rna complex]]
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Current revision

Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-AAP1

PDB ID 5uhe

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