4ws8

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==Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 2-thiouracil, Form V==
==Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 2-thiouracil, Form V==
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<StructureSection load='4ws8' size='340' side='right' caption='[[4ws8]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4ws8' size='340' side='right'caption='[[4ws8]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ws8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WS8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ws8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WS8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TUL:2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE'>TUL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wru|4wru]], [[4wrv|4wrv]], [[4wrw|4wrw]], [[4wrx|4wrx]], [[4wry|4wry]], [[4wrz|4wrz]], [[4ws0|4ws0]], [[4ws1|4ws1]], [[4ws2|4ws2]], [[4ws3|4ws3]], [[4ws4|4ws4]], [[4ws5|4ws5]], [[4ws6|4ws6]], [[4ws7|4ws7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TUL:2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE'>TUL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ws8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ws8 OCA], [https://pdbe.org/4ws8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ws8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ws8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ws8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ws8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ws8 OCA], [http://pdbe.org/4ws8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ws8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ws8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ws8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
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[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DNA glycosylase|DNA glycosylase]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Uracil-DNA glycosylase]]
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[[Category: Large Structures]]
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[[Category: Arif, S M]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Geethanandan, K]]
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[[Category: Arif SM]]
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[[Category: Mishra, P]]
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[[Category: Geethanandan K]]
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[[Category: Surolia, A]]
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[[Category: Mishra P]]
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[[Category: Varshney, U]]
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[[Category: Surolia A]]
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[[Category: Vijayan, M]]
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[[Category: Varshney U]]
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[[Category: Conformational selection]]
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[[Category: Vijayan M]]
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[[Category: Dna-repair]]
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[[Category: Excision repair]]
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[[Category: Hydrolase]]
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[[Category: Ligand-binding]]
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Current revision

Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 2-thiouracil, Form V

PDB ID 4ws8

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