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4caj

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==Crystallographic structure of the mouse SIGN-R1 CRD domain in complex with sialic acid==
==Crystallographic structure of the mouse SIGN-R1 CRD domain in complex with sialic acid==
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<StructureSection load='4caj' size='340' side='right' caption='[[4caj]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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<StructureSection load='4caj' size='340' side='right'caption='[[4caj]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4caj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4caj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.191&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c9f|4c9f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caj OCA], [http://pdbe.org/4caj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caj RCSB], [http://www.ebi.ac.uk/pdbsum/4caj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4caj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caj OCA], [https://pdbe.org/4caj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caj RCSB], [https://www.ebi.ac.uk/pdbsum/4caj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C209B_MOUSE C209B_MOUSE]] Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
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[https://www.uniprot.org/uniprot/C209B_MOUSE C209B_MOUSE] Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bartual, S G]]
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[[Category: Large Structures]]
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[[Category: Hermoso, J A]]
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[[Category: Mus musculus]]
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[[Category: Silva-Martin, N]]
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[[Category: Bartual SG]]
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[[Category: C-lectin crd]]
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[[Category: Hermoso JA]]
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[[Category: Capsular polysaccharide]]
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[[Category: Silva-Martin N]]
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[[Category: Immune system]]
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[[Category: Sign-r1]]
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Current revision

Crystallographic structure of the mouse SIGN-R1 CRD domain in complex with sialic acid

PDB ID 4caj

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