Enoyl-Acyl-Carrier Protein Reductase

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<StructureSection load='3fne' size='350' side='right' scene='43/434541/Cv/3' caption='Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code [[3fne]]) '>
<StructureSection load='3fne' size='350' side='right' scene='43/434541/Cv/3' caption='Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code [[3fne]]) '>
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__TOC__
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==Function==
[[Enoyl-Acyl-Carrier Protein Reductase]] (ENR) is an enzyme in the fatty acid synthesis. For additional details see<br />
[[Enoyl-Acyl-Carrier Protein Reductase]] (ENR) is an enzyme in the fatty acid synthesis. For additional details see<br />
*[[InhA]] - NADH-dependent trans ENR<br />
*[[InhA]] - NADH-dependent trans ENR<br />
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*[[Fatty acid synthesis]]
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='43/434541/Cv/4'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene>. InhA ENR <scene name='43/434541/Cv/9'>active site contains NAD and TCL</scene>.<ref>PMID:19130456</ref>
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<scene name='43/434541/Cv/10'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene>. InhA ENR <scene name='43/434541/Cv/11'>active site contains NAD and triclosan derivative</scene>.<ref>PMID:19130456</ref>
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</StructureSection>
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== 3D Structures of Enoyl-Acyl-Carrier Protein Reductase ==
== 3D Structures of Enoyl-Acyl-Carrier Protein Reductase ==
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[[Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Enoyl-acyl-carrier protein reductase
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**[[3oic]] – BsENR III – ''Bacillus subtilis''<BR />
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**[[4trm]] - MtENR - ''Mycobacterium tuberculosis''<BR />
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**[[2ied]] - MtENR (mutant) <BR />
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**[[3oje]] – BcENR – ''Bacillus cereus''<br />
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**[[3gns]], [[3gnt]] – SaENR – ''Staphylococcus aureus''<br />
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**[[4alm]], [[4aln]] - SaENR (mutant)<br />
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**[[2p91]] – ENR – ''Aquifex aeolicus''<br />
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**[[2o50]] - TgENR – ''Toxoplasma gondii''<br />
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**[[2ptg]] – ENR – ''Eimeria tenella''<br />
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**[[1gu7]] – CtENR – ''Candida tropicalis''<br />
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**[[4w99]] - CtENR (mutant)<br />
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**[[1ulu]], [[2wyu]] – TtENR – ''Thermus thermophilus''<br />
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**[[3grk]] – BmENR – ''Brucella melitensis''<br />
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**[[3k2e]] – ApENR – ''Anaplasma phagocytophilum''<br />
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**[[4eit]] – BhENR – ''Bartonella henselae''<br />
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**[[3ek2]], [[5i7e]] – BpENR – ''Burkholderia pseudomallei''<br />
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**[[4nk4]] – ClENR – ''Candidatus liberibacter''<br />
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**[[4m86]] - NmENR – ''Neisseria meningitidis''<br />
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**[[4nqz]] - PaENR – ''Pseudomonas aeruginosa''<br />
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**[[5cfz]] - EcENR – ''Escherichia coli''<br />
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**[[5gvj]] - ENR (mutant) – ''Thermotoga maritima''<br />
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*Enoyl-Acyl-Carrier Protein Reductase binary complex with NAD
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**[[3oew]], [[2x22]], [[2x23]], [[1eny]], [[1enz]], [[4dqu]], [[4dre]], [[4trn]] – MtENR+NAD<BR />
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**[[3of2]], [[4dti]] – MtENR (mutant)+NAD<BR />
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**[[2pr2]], [[2idz]], [[2h9i]] – MtENR+INH-NAPD<br />
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**[[2aq8]] – MtENR+NADH<br />
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**[[2aqh]], [[2aqi]], [[2aqk]], [[3oey]] – MtENR (mutant)+NADH<BR />
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**[[2ntj]] – MtENR+PTH-NAD<BR />
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**[[2ntv]] - ENR+PTH-NAD – ''Mycobacterium leprae''<br />
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**[[1vrw]], [[1v35]] – PfENR+NAD<BR />
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**[[2nq8]] – PfENR+INH-NAD<BR />
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**[[1eno]], [[1enp]] - BnENR (mutant)+NAD – ''Brassica napus''<br />
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**[[1guf]] – CtENR + NAD<br />
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**[[2jjy]] – FtENR + NAD – ''Francisella tularensis''<br />
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**[[2wyv]] - TtENR + NAD<br />
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**[[3k31]] – ApENR + NAD<br />
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**[[4nk5]] – ClENR + NAD <br />
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**[[5koi]] – BmENR + NAD <br />
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**[[5tf4]] – BhENR + NAD <br />
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**[[4zju]] – ENR + NAD – ''Acinetobacter baumannii''<br />
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**[[5g2o]], [[5jai]], [[5jam]], [[5jaq]] – ENR (mutant) + NAD – ''Yersinia pestis''<br />
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**[[4m87]] - NmENR+NAD<br />
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**[[5trt]] – BpENR + NAD<br />
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*Other enoyl-Acyl-Carrier Protein Reductase binary complexes
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**[[2ie0]], [[2ieb]], [[2nv6]], [[1zid]] – MtENR (mutant)+INH-NAPD<br />
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**[[2foi]] – PfENR fragment+diaryl ether inhibitor<br />
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**[[2pd3]] – HpENR+TCL – ''Helicobacter pylori''<br />
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**[[2yw9]] – TtENR + NADP<br />
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**[[2fhs]] - EcENR+ acyl carrier protein <br />
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**[[2z6i]] – SpENR II + FMN – ''Streptococcus pneumoniae''<br />
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**[[4fs3]] – SaENR + inhibitor<br />
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**[[4rlh]] – BpENR + inhibitor<br />
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**[[4w9n]] – ENR + TCL - human<br />
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*Enoyl-Acyl-Carrier Protein Reductase ternary complex
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**[[3oid]] – BsENR III+NADP+TCL<BR />
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**[[3oif]] – BsENR I+NAD+TCL<BR />
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**[[3oig]] – BsENR I+NAD+INH<br />
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**[[2o2s]] - TgENR +NAD+TCL<br />
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**[[3nj8]] - TgENR +NAD+TCL derivative<br />
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**[[3fne]], [[3fnf]], [[3fng]], [[3fnh]], [[2b35]], [[1p45]] – MtENR+NAD+TCL<BR />
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**[[2wyw]] - TtENR+NAD+TCL<br />
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**[[2b36]], [[2b37]], [[4ohu]], [[4oim]], [[4oyr]] – MtENR+NAD+phenoxyphenol derivative<br />
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**[[2nsd]] – MtENR+NAD+piperidine derivative<br />
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**[[4u0j]], [[4tzt]], [[4tzk]], [[4trj]], [[4u0k]] - MtENR+NAD+pyrrolidine derivative<br />
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**[[4cod]], [[4bqp]], [[4bqr]], [[4bge]], [[4bii]], [[4oxk]], [[4oxn]], [[4oxy]], [[4r9r]], [[4r9s]], [[4d0r]], [[4d0s]], [[4qxm]], [[4tro]], [[4uvd]], [[4uve]], [[4uvg]], [[4uvh]], [[4uvi]], [[5g0s]], [[5g0t]], [[5g0u]], [[5g0v]], [[5g0w]], [[5jfo]], [[5mtp]], [[5mtq]], [[5mtr]], [[5ugs]], [[5ugt]], [[5ugu]] - MtENR+NAD + inhibitor<br />
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**[[4bgi]], [[5coq]], [[5cp8]], [[5cpb]], [[5cpf]] - MtENR (mutant) +NAD + inhibitor<br />
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**[[1p44]] - MtENR+NAD+indole derivative<br />
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**[[1bvr]] - MtENR+NAD+fatty-acyl substrate<br />
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**[[3ojf]] – BcENR+NADP+indole naphthyrididone<br />
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**[[3lsy]], [[3lt0]], [[3lt1]], [[3lt2]], [[3lt4]], [[1uh5]] – PfENR fragment+NAD+TCL – ''Plasmodium falciparum''<br />
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**[[2ol4]], [[2oos]], [[2op0]], [[2op1]], [[2o2y]], [[1zxb]], [[1zxl]], [[1zw1]], [[1zsn]], [[1nhg]] – PfENR+NAD+TCL<BR />
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**[[1nhw]], [[1nnu]] - PfENR+NAD+TCL analog<br />
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**[[3gr6]], [[4all]] – SaENR+NAD+TCL<BR />
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**[[4ali]] – SaENR (mutant) +NADP +TCL<br />
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**[[4alj]], [[4alk]], [[4bnf]], [[4bng]], [[4bnh]], [[4bni]], [[4bnj]], [[4bnk]], [[4bnl]], [[4bnm]], [[4bnn]], [[4d41]], [[4d42]], [[4d43]], [[4d45]] – SaENR (mutant) +NADP + phenoxyphenol derivative<br />
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**[[4cv2]], [[4cv3]] – SaENR +NAD + inhibitor<br />
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**[[4cuz]], [[4cv0]], [[4cv1]], [[4d44]], [[3nz9]] – SaENR (mutant) +NADP + inhibitor<br />
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**[[4nz9]] – SaENR +NADP + inhibitor<br />
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**[[2qio]] - ENR+NAD+TCL – ''Bacillus anthracis''<br />
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**[[2pd4]] – HpENR+NAD+diclosan<br />
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**[[1mfp]], [[1i30]] - EcENR+NAD+indole derivative <br />
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**[[1lx6]], [[1lxc]] - EcENR+NAD+amide derivative<br />
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**[[1i2z]] - EcENR+NAD+imidazole derivative<br />
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**[[1dfg]], [[1dfh]], [[1dfi]] - EcENR+NAD+ diazoborin derivative<br />
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**[[1qsg]], [[1d8a]], [[1c14]], [[1qg6]] - EcENR+NAD+TCL<BR />
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**[[3pjd]], [[3pje]], [[3pjf]] – EcENR (mutant) +NAD+TCL<br />
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**[[4d46]], [[4jqc]], [[4jx8]], [[5cg1]], [[5cg2]] – EcENR +NAD + inhibitor<br />
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**[[3nrc]] - FtENR+NAD+TCL<br />
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**[[3uic]], [[4j1n]], [[4j3f]], [[4j4t]] - FtENR+NAD+imidazole derivative<br />
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**[[1d7o]] - BnENR+NAD+TCL<br />
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**[[1cwu]] – BnENR (mutant)+NAD+thienodiazaborine<br />
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**[[2z6j]] – SpENR II + FMN + inhibitor<br />
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**[[3f4b]] - ENR+NAD+TCL – ''Plasmodium berghei''<br />
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**[[4m89]] - NmENR+NAD+TCL <br />
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**[[4iql]] – ENR + NADPH + FMN – ''Porphyromonas gingivalis''<br />
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**[[4bku]], [[5i7f]], [[5i7s]], [[5i7v]], [[5i8w]], [[5i8z]], [[5i9l]], [[5i9m]], [[5i9n]] - BpENR+NAD+ inhibitor<br />
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**[[5ifl]] - BpENR+NAD+TCL <br />
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**[[4q9n]] - ENR+NAD+ inhibitor – ''Chlamydia trachomatis''<br />
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**[[4nr0]] - PaENR+NAD+TCL <br />
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**[[4was]] – CtENR + NADPH + crotonyl CoA<br />
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}}
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== References ==
== References ==

Current revision

Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code 3fne)

Drag the structure with the mouse to rotate

References

  1. ↑ Freundlich JS, Wang F, Vilcheze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. ChemMedChem. 2009 Jan 7. PMID:19130456 doi:10.1002/cmdc.200800261

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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