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Ephrin

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Current revision (11:27, 21 February 2023) (edit) (undo)
 
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<StructureSection load='3mx0' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2 (PDB code [[3mx0]]).' scene='59/594659/Cv/1'>
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<StructureSection load='' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code [[3mx0]]).' scene='59/594659/Cv/5'>
== Function ==
== Function ==
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'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>.
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'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], [[Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]].
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='59/594659/Cv/2'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref>
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<scene name='59/594659/Cv/4'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref>
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Ephrin-A1
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**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
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**[[3fl7]] – hEph ectodomain <br />
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*Ephrin-A2
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**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
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* Ephrin-A3
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**[[3dzq]] – hEph kinase domain + inhibitor <br />
*Ephrin-A5
*Ephrin-A5
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**[[1shx]] – mEph receptor-binding domain – mouse<br />
 
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**[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br />
 
**[[2x11]], [[3mx0]] – hEph receptor-binding domain + Eph type A receptor 2 - human<br />
**[[2x11]], [[3mx0]] – hEph receptor-binding domain + Eph type A receptor 2 - human<br />
**[[4bk5]], [[4bka]], [[4m4r]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
**[[4bk5]], [[4bka]], [[4m4r]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
**[[4l0p]] – hEph receptor-binding domain + Eph type A receptor 3 <br />
**[[4l0p]] – hEph receptor-binding domain + Eph type A receptor 3 <br />
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**[[1shx]] – mEph receptor-binding domain – mouse<br />
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**[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br />
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*Ephrin-B1
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**[[6thg]] – hEph extracellular domain 27-170 + glycoprotein <br />
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**[[6p7s]] – mEph extracellular domain + glycoprotein <br />
*Ephrin-B2
*Ephrin-B2
**[[2i85]] – hEph residues 1-142 – NMR<br />
**[[2i85]] – hEph residues 1-142 – NMR<br />
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**[[1iko]] – mEph ectodomain <br />
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**[[2wo2]], [[3gxu]] – hEph extracellular domain + Eph type A receptor 4 <br />
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**[[1kgy]] – mEph receptor-binding domain + Eph type B receptor 2 <br />
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**[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br />
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**[[2hle]] – mEph receptor-binding domain + Eph type B receptor 4 <br />
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**[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br />
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**[[2wo2]], [[3gxu]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
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**[[1iko]], [[7s7k]] – mEph ectodomain <br />
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**[[4uf7]] – hEph receptor-binding domain + glycoprotein <br />
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**[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br />
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**[[2vsk]], [[2vsm]] – hEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
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**[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br />
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**[[6p7y]] – mEph extracellular domain + glycoprotein <br />
*Ephrin-B3
*Ephrin-B3
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**[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
 
**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
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**[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
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*Ephrin-A1
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+
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**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
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**[[3fl7]] – hEph ectodomain <br />
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-
 
+
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*Ephrin-A2
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**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
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+
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* Ephrin-A3
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**[[3dzq]] – hEph kinase domain + inhibitor <br />
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}}
}}

Current revision

Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code 3mx0).

Drag the structure with the mouse to rotate

3D structures of ephrin

Updated on 21-February-2023


References

  1. ↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004
  2. ↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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