4wp0
From Proteopedia
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==Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag== | ==Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag== | ||
| - | <StructureSection load='4wp0' size='340' side='right' caption='[[4wp0]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='4wp0' size='340' side='right'caption='[[4wp0]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wp0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP0 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4wp0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WP0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wp0 OCA], [https://pdbe.org/4wp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wp0 RCSB], [https://www.ebi.ac.uk/pdbsum/4wp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wp0 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Akladios FN]] |
| - | [[Category: | + | [[Category: Church WB]] |
| - | [[Category: | + | [[Category: Collyer CA]] |
| - | [[Category: | + | [[Category: Gorrell MD]] |
| - | [[Category: | + | [[Category: Kapoor V]] |
| - | [[Category: | + | [[Category: Nadvi NA]] |
| - | [[Category: | + | [[Category: Park J]] |
| - | [[Category: | + | [[Category: Salam NK]] |
| - | + | ||
Current revision
Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag
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Categories: Homo sapiens | Large Structures | Akladios FN | Church WB | Collyer CA | Gorrell MD | Kapoor V | Nadvi NA | Park J | Salam NK
