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5g4c

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==Human SIRT2 catalyse short chain fatty acyl lysine==
==Human SIRT2 catalyse short chain fatty acyl lysine==
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<StructureSection load='5g4c' size='340' side='right' caption='[[5g4c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5g4c' size='340' side='right'caption='[[5g4c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5g4c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G4C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5g4c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G4C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6G4:4-OXONONANOYL)LYSINE'>6G4</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6G4:4-OXONONANOYL)LYSINE'>6G4</scene>, <scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4c OCA], [http://pdbe.org/5g4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g4c RCSB], [http://www.ebi.ac.uk/pdbsum/5g4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4c OCA], [https://pdbe.org/5g4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g4c RCSB], [https://www.ebi.ac.uk/pdbsum/5g4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
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[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5g4c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5g4c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Wang, Y]]
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[[Category: Homo sapiens]]
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[[Category: Acyl]]
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[[Category: Large Structures]]
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[[Category: Adpr]]
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[[Category: Wang Y]]
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[[Category: Hdac]]
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[[Category: Hydrolase]]
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[[Category: Nad dependent]]
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[[Category: Sirtuin class i]]
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Current revision

Human SIRT2 catalyse short chain fatty acyl lysine

PDB ID 5g4c

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