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5gse

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==Crystal structure of unusual nucleosome==
==Crystal structure of unusual nucleosome==
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<StructureSection load='5gse' size='340' side='right' caption='[[5gse]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
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<StructureSection load='5gse' size='340' side='right'caption='[[5gse]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gse]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GSE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gse]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GSE FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gse OCA], [http://pdbe.org/5gse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gse RCSB], [http://www.ebi.ac.uk/pdbsum/5gse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gse ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gse OCA], [https://pdbe.org/5gse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gse RCSB], [https://www.ebi.ac.uk/pdbsum/5gse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gse ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
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[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5gse" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5gse" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arimura, Y]]
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[[Category: Homo sapiens]]
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[[Category: Kato, D]]
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[[Category: Large Structures]]
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[[Category: Kurumizaka, H]]
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[[Category: Synthetic construct]]
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[[Category: Osakabe, A]]
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[[Category: Arimura Y]]
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[[Category: Park, S Y]]
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[[Category: Kato D]]
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[[Category: Dna-binding]]
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[[Category: Kurumizaka H]]
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[[Category: Histone-fold]]
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[[Category: Osakabe A]]
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[[Category: Nucleus]]
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[[Category: Park SY]]
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[[Category: Structural protein-dna complex]]
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Crystal structure of unusual nucleosome

PDB ID 5gse

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