5tuv

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==Crystal structure of the E2F5-DP1-p107 ternary complex==
==Crystal structure of the E2F5-DP1-p107 ternary complex==
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<StructureSection load='5tuv' size='340' side='right' caption='[[5tuv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='5tuv' size='340' side='right'caption='[[5tuv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tuv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tuv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUV FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tuu|5tuu]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tuv OCA], [http://pdbe.org/5tuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tuv RCSB], [http://www.ebi.ac.uk/pdbsum/5tuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tuv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tuv OCA], [https://pdbe.org/5tuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tuv RCSB], [https://www.ebi.ac.uk/pdbsum/5tuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tuv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN]] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref> [[http://www.uniprot.org/uniprot/RBL1_HUMAN RBL1_HUMAN]] Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. [[http://www.uniprot.org/uniprot/E2F5_HUMAN E2F5_HUMAN]] Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.[UniProtKB:Q6DE14]
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[https://www.uniprot.org/uniprot/TFDP1_HUMAN TFDP1_HUMAN] Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).<ref>PMID:20176812</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Liban, T J]]
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[[Category: Homo sapiens]]
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[[Category: Rubin, S M]]
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[[Category: Large Structures]]
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[[Category: Tripathi, S M]]
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[[Category: Liban TJ]]
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[[Category: Cell-cycle regulation]]
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[[Category: Rubin SM]]
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[[Category: Transcription]]
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[[Category: Tripathi SM]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of the E2F5-DP1-p107 ternary complex

PDB ID 5tuv

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