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5bpu

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==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
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<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='5bpu' size='340' side='right'caption='[[5bpu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4my2|4my2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://pdbe.org/5bpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [https://pdbe.org/5bpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [https://www.ebi.ac.uk/pdbsum/5bpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpu ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
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[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chang, T H]]
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[[Category: Homo sapiens]]
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[[Category: Harlos, K]]
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[[Category: Large Structures]]
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[[Category: Hsieh, F L]]
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[[Category: Synthetic construct]]
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[[Category: Jones, E Y]]
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[[Category: Chang T-H]]
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[[Category: Cystine-knot like growth factor]]
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[[Category: Harlos K]]
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[[Category: Ligand for frizzled 4 receptor]]
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[[Category: Hsieh F-L]]
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[[Category: Norrie disease protein]]
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[[Category: Jones EY]]
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[[Category: Signaling protein]]
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[[Category: Wnt signalling pathway]]
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Current revision

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I

PDB ID 5bpu

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