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5b3a

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==Crystal Structure of O-Phoshoserine Sulfhydrylase from Aeropyrum pernix in Complexed with the alpha-Aminoacrylate Intermediate==
==Crystal Structure of O-Phoshoserine Sulfhydrylase from Aeropyrum pernix in Complexed with the alpha-Aminoacrylate Intermediate==
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<StructureSection load='5b3a' size='340' side='right' caption='[[5b3a]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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<StructureSection load='5b3a' size='340' side='right'caption='[[5b3a]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5b3a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B3A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5b3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B3A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0JO:2-{[(E)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE]AMINO}PROP-2-ENOIC+ACID'>0JO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b36|5b36]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JO:2-{[(E)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE]AMINO}PROP-2-ENOIC+ACID'>0JO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b3a OCA], [http://pdbe.org/5b3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b3a RCSB], [http://www.ebi.ac.uk/pdbsum/5b3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b3a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b3a OCA], [https://pdbe.org/5b3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b3a RCSB], [https://www.ebi.ac.uk/pdbsum/5b3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b3a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSO_AERPE CYSO_AERPE]] Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide.<ref>PMID:12644499</ref>
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[https://www.uniprot.org/uniprot/CYSO_AERPE CYSO_AERPE] Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide.<ref>PMID:12644499</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ishikawa, K]]
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[[Category: Aeropyrum pernix K1]]
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[[Category: Kataoka, M]]
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[[Category: Large Structures]]
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[[Category: Kawai, Y]]
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[[Category: Ishikawa K]]
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[[Category: Nakamura, T]]
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[[Category: Kataoka M]]
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[[Category: Takeda, E]]
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[[Category: Kawai Y]]
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[[Category: Cysteine biosynthesis]]
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[[Category: Nakamura T]]
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[[Category: External schiff base of plp with alpha-amino acrylate]]
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[[Category: Takeda E]]
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[[Category: Intermediate]]
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[[Category: Sulfhydrylase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of O-Phoshoserine Sulfhydrylase from Aeropyrum pernix in Complexed with the alpha-Aminoacrylate Intermediate

PDB ID 5b3a

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