5nff

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==Crystal structure of GP1 receptor binding domain from Morogoro virus==
==Crystal structure of GP1 receptor binding domain from Morogoro virus==
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<StructureSection load='5nff' size='340' side='right' caption='[[5nff]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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<StructureSection load='5nff' size='340' side='right'caption='[[5nff]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nff]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NFF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nff]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Morogoro_mammarenavirus Morogoro mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NFF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.615&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nff OCA], [http://pdbe.org/5nff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nff RCSB], [http://www.ebi.ac.uk/pdbsum/5nff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nff ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nff OCA], [https://pdbe.org/5nff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nff RCSB], [https://www.ebi.ac.uk/pdbsum/5nff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nff ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C6ZK00_MOPEI C6ZK00_MOPEI] Forms the virion spikes together with glycoprotein G2. The glycoprotein spike trimers are connected to the underlying matrix. Interacts with the host receptor leading to virus endocytosis.[HAMAP-Rule:MF_04084] Forms the virion spikes together with glycoprotein G1. The glycoprotein spike trimers are connected to the underlying matrix. Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced by acidification.[HAMAP-Rule:MF_04084] Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C). Helps to stabilize the spike complex in its native conformation. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nff" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nff" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cohen-Dvashi, H]]
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[[Category: Large Structures]]
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[[Category: Diskin, R]]
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[[Category: Morogoro mammarenavirus]]
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[[Category: Israeli, H]]
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[[Category: Cohen-Dvashi H]]
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[[Category: Shimon, A]]
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[[Category: Diskin R]]
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[[Category: Shulman, A]]
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[[Category: Israeli H]]
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[[Category: Glycoprotein]]
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[[Category: Shimon A]]
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[[Category: Receptor binding-domain]]
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[[Category: Shulman A]]
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[[Category: Viral envelope]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of GP1 receptor binding domain from Morogoro virus

PDB ID 5nff

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