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5xk0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5xk0 is ON HOLD Authors: Liu, H.H., Gan, J.H. Description: Structure of 8mer DNA2 Category: Unreleased Structures Category: Gan, J.H [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 8-mer DNA2== | |
| + | <StructureSection load='5xk0' size='340' side='right'caption='[[5xk0]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5xk0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XK0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.451Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xk0 OCA], [https://pdbe.org/5xk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xk0 RCSB], [https://www.ebi.ac.uk/pdbsum/5xk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xk0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between Ag(I) and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices. | ||
| - | + | A DNA Structure Containing Ag(I) -Mediated G:G and C:C Base Pairs.,Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J, Sheng J, Gan J Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9430-9434. doi: 10.1002/anie.201704891., Epub 2017 Jul 7. PMID:28635152<ref>PMID:28635152</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Gan | + | <div class="pdbe-citations 5xk0" style="background-color:#fffaf0;"></div> |
| - | [[Category: Liu | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Gan JH]] | ||
| + | [[Category: Liu HH]] | ||
Current revision
Structure of 8-mer DNA2
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