5xgr

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==Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein==
==Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein==
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<StructureSection load='5xgr' size='340' side='right' caption='[[5xgr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5xgr' size='340' side='right'caption='[[5xgr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XGR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pipistrellus_bat_coronavirus_HKU5 Pipistrellus bat coronavirus HKU5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XGR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xgr OCA], [http://pdbe.org/5xgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xgr RCSB], [http://www.ebi.ac.uk/pdbsum/5xgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xgr ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xgr OCA], [https://pdbe.org/5xgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xgr RCSB], [https://www.ebi.ac.uk/pdbsum/5xgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xgr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5]] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
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[https://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5xgr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5xgr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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*[[Spike protein 3D structures|Spike protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gao, G F]]
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[[Category: Large Structures]]
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[[Category: Qi, J]]
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[[Category: Pipistrellus bat coronavirus HKU5]]
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[[Category: Qihui, W]]
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[[Category: Gao GF]]
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[[Category: Shi, Y]]
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[[Category: Qi J]]
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[[Category: Song, H]]
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[[Category: Qihui W]]
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[[Category: Xue, H]]
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[[Category: Shi Y]]
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[[Category: Batcov hku5]]
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[[Category: Song H]]
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[[Category: Ctd]]
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[[Category: Xue H]]
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[[Category: Evolution]]
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[[Category: Mers-cov]]
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[[Category: Viral protein]]
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Current revision

Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein

PDB ID 5xgr

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