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5mim

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==Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n==
==Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n==
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<StructureSection load='5mim' size='340' side='right' caption='[[5mim]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5mim' size='340' side='right'caption='[[5mim]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mim]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MIM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MIM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1N:1-[(1~{R},2~{R},4~{S},5~{S})-2,4-BIS(4-CARBAMIMIDAMIDOPHENOXY)-5-[(4-CARBAMIMIDAMIDOPHENYL)AMINO]CYCLOHEXYL]GUANIDINE'>1N</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Furin Furin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.75 3.4.21.75] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1N:1-[(1~{R},2~{R},4~{S},5~{S})-2,4-BIS(4-CARBAMIMIDAMIDOPHENOXY)-5-[(4-CARBAMIMIDAMIDOPHENYL)AMINO]CYCLOHEXYL]GUANIDINE'>1N</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mim OCA], [http://pdbe.org/5mim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mim RCSB], [http://www.ebi.ac.uk/pdbsum/5mim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mim ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mim OCA], [https://pdbe.org/5mim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mim RCSB], [https://www.ebi.ac.uk/pdbsum/5mim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mim ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FURIN_HUMAN FURIN_HUMAN]] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.<ref>PMID:7690548</ref>
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[https://www.uniprot.org/uniprot/FURIN_HUMAN FURIN_HUMAN] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.<ref>PMID:7690548</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mim" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mim" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Furin|Furin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Furin]]
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[[Category: Homo sapiens]]
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[[Category: Dahms, S O]]
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[[Category: Large Structures]]
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[[Category: Guan-Sheng, J]]
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[[Category: Dahms SO]]
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[[Category: Than, M E]]
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[[Category: Guan-Sheng J]]
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[[Category: Complex]]
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[[Category: Than ME]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Proprotein convertase]]
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[[Category: Protease]]
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Current revision

Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n

PDB ID 5mim

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