|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[5m35]] This PDB entry is obsolete and replaced by 5m35 |
| - | ==Molecular tweezers stabilize a disordered protein-protein interface==
| + | |
| - | <StructureSection load='5jit' size='340' side='right' caption='[[5jit]], [[Resolution|resolution]] 2.38Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[5jit]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIT FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
| + | |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
| + | |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jit OCA], [http://pdbe.org/5jit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jit RCSB], [http://www.ebi.ac.uk/pdbsum/5jit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jit ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> [[http://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN]] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Protein-tyrosine-phosphatase]]
| + | |
| - | [[Category: Bier, D]]
| + | |
| - | [[Category: Ottmann, C]]
| + | |
| - | [[Category: 14-3-3 protein]]
| + | |
| - | [[Category: Ppi stabilization]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Supramolecular ligand]]
| + | |
