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| - | | + | #REDIRECT [[5m36]] This PDB entry is obsolete and replaced by 5m36 |
| - | ==Molecular tweezers stabilize a disordered protein-protein interface==
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| - | <StructureSection load='5jiv' size='340' side='right' caption='[[5jiv]], [[Resolution|resolution]] 2.45Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5jiv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIV FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19O:NATRIUM-(5,7+,9+,11+,16+,18+,20+,22+)-5,7,9,11,16,18,20,22-OCTAHYDRO-5,22 7,20 9,18 11,16-TETRAMETHANONONACEN-8,19-BISPHOSPHATE'>19O</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jiv OCA], [http://pdbe.org/5jiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jiv RCSB], [http://www.ebi.ac.uk/pdbsum/5jiv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jiv ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> [[http://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN]] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Protein-tyrosine-phosphatase]]
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| - | [[Category: Bier, D]]
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| - | [[Category: Ottmann, C]]
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| - | [[Category: 14-3-3 protein]]
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| - | [[Category: Ppi stabilization]]
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| - | [[Category: Signaling protein]]
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| - | [[Category: Supramolecular ligand]]
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