5uni

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==Critical role of water molecules for proton translocation of the membrane-bound transhydrogenase==
==Critical role of water molecules for proton translocation of the membrane-bound transhydrogenase==
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<StructureSection load='5uni' size='340' side='right' caption='[[5uni]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5uni' size='340' side='right'caption='[[5uni]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UNI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)(+)_transhydrogenase_(Re/Si-specific) NAD(P)(+) transhydrogenase (Re/Si-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.1.2 1.6.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uni OCA], [http://pdbe.org/5uni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uni RCSB], [http://www.ebi.ac.uk/pdbsum/5uni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uni ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uni OCA], [https://pdbe.org/5uni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uni RCSB], [https://www.ebi.ac.uk/pdbsum/5uni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uni ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q72GS0_THET2 Q72GS0_THET2]] The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity).[PIRNR:PIRNR000204]
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[https://www.uniprot.org/uniprot/Q72GR9_THET2 Q72GR9_THET2]
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==See Also==
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*[[NAD(P) transhydrogenase 3D structures|NAD(P) transhydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leung, J H]]
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[[Category: Large Structures]]
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[[Category: Padayatti, P S]]
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[[Category: Thermus thermophilus]]
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[[Category: High resolution]]
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[[Category: Leung JH]]
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[[Category: Oxidoreductase]]
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[[Category: Padayatti PS]]
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[[Category: Proton channel]]
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[[Category: Transmembrane]]
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Critical role of water molecules for proton translocation of the membrane-bound transhydrogenase

PDB ID 5uni

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